DRIVE sample size tool has been developed by P95 for simulation-based sample size. This web application allows to perform sample size calculations for cohort and test negative design studies on brand-specific and overall vaccine efficacy. Sample size requirements are expressed in terms of both minimal detectable vaccine efficacy and precision (here defined as the expected lower limit of the 95% confidence interval of the anticipated Vaccine effectiveness). The application allows uses to input parameters (e.g. study design, case-control ratio, disease attack rate, overall and brand-specific vaccination coverage, number of subtypes/strains) and to obtain graphical and tabular sample size outputs.

Please CLICK HERE to access the tool